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Some of the host factors affecting susceptibility to HIV-1 infection
| Innate | Genetic | Acquired | Intrinsic |
|---|---|---|---|
| Autoantibodies | HLA haplotype | Cytotoxic T-cell activity | APOBEC3G/3F |
| Chemokines | CCR5 gene/promoter | Helper T-cell function | TRIM5α |
| Cytokines | CCR2 gene/promoter | Neutralising antibodies | |
| CCL3L1 gene copy number |
HLA=human leucocyte antigen. CCR5=chemokine receptor 5. CCR2=chemokine receptor 2. CCL3L1=CC chemokine ligand like-1, APOBEC3G/3F=apolipoprotein B mRNA editing complex 3.
