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. Author manuscript; available in PMC: 2010 Aug 2.
Published in final edited form as: Neuron. 2008 Oct 23;60(2):273–284. doi: 10.1016/j.neuron.2008.09.026

Figure 2. Notch signaling is required for proper radial migration of cortical neurons.

Figure 2

(A) Schematic representation of Notch genomic deletion in the migrating neurons. (B-E) Venus immunostaining 6 days post-electroporation with pTα1-Cre-IRES-Venus (B-D) or pTα1-IRES-Venus (E) into indicated mice. Bar (μm) = 100. Dashed lines indicate pial and ventricular surfaces. (F) The graphs indicate quantification of the distribution of Venus+ neurons in the 10 bins dividing the whole thickness of the cortex as indicated in B in each genotype. The data represent the mean ± SEM of 4 brains each from independent experiments. p<0.0001, p<0.0001, and p>0.05 for rl/rl, Notch1fl/fl;Notch2fl/fl(+Cre) and Notch1fl/fl;Notch2fl/fl(−Cre), respectively compared with wild-type by Two-sample Kolmogorov-Smirnov test (K-S test). F(9,54)=107.40, p<0.0001, F(9,45)=54.92, p<0.0001, and F(9,54)=0.78, p>0.05, respectively by Repeated Measures ANOVA.