TABLE III.

Associations between ARG1 and ARG2 haplotypes and asthma

Gene, haplotypes	Non-Hispanic white	Hispanic white	Combined
	OR (95% CI)*	OR (95% CI)*	OR (95% CI)*
ARG1 haplotypes†
ARG1h1	1.0 (Reference)	1.0 (Reference)	1.0 (Reference)
ARG1h2	0.96 (0.72–1.28)	0.85 (0.56–1.28)	0.93 (0.74–1.17)
ARG1h3	1.00 (0.74–1.36)	1.23 (0.76–1.98)	1.06 (0.82–1.37)
ARG1h4	0.61 (0.37–1.00)	0.41 (0.17–0.97)	0.55 (0.36–0.84)
ARG1h5	1.33 (0.85–2.09)	1.01 (0.57–1.77)	1.22 (0.87–1.72)
ARG1h6	0.83 (0.38–1.81)	0.57 (0.23–1.38)	0.69 (0.39–1.21)
Other haplotypes	0.96 (0.66–1.39)	0.99 (0.55–1.77)	0.95 (0.70–1.29)
Global P-value‡	0.39	0.18	0.04
ARG2 haplotypes†
ARG2h1	1.0 (Reference)	1.0 (Reference)	1.0 (Reference)
ARG2h2	1.30 (0.97–1.73)	1.10 (0.67–1.82)	1.22 (0.96–1.56)
ARG2h3	1.38 (1.02–1.87)	1.28 (0.73–2.26)	1.35 (1.04–1.76)
ARG2h4	1.00 (0.72–1.39)	0.89 (0.50–1.61)	0.98 (0.74–1.30)
ARG2h5	0.86 (0.58–1.27)	0.68 (0.31–1.51)	0.83 (0.59–1.18)
ARG2h6	0.50 (0.28–0.92)	1.28 (0.60–2.71)	0.73 (0.47–1.15)
ARG2h7	0.74 (0.41–1.32)	0.96 (0.57–1.63)	0.88 (0.61–1.26)
ARG2h8	0.80 (0.09–7.18)	0.87 (0.41–1.86)	0.79 (0.40–1.54)
Other haplotypes	1.37 (0.99–1.91)	1.19 (0.71–2.00)	1.30 (0.99–1.71)
Global P-value‡	0.007	0.89	0.02

^*ORs are calculated using the most common haplotype as reference and represent the risk associated with per copy of the haplotype. ORs are adjusted for age, sex, ethnicity (for the combined population), child’s atopic status, parental history of asthma, parent/guardian’s education, in utero exposure to maternal smoking, exposure to secondhand smoke, health insurance coverage, and community of residence.

^†For the order of SNPs in haplotypes, see the footnote of Table I.

^‡Global P-values are from likelihood ratio tests compared to a model with no haplotype data and were based on 6df for ARG1 and 8df for ARG2.