. Author manuscript; available in PMC: 2010 Aug 2.

Published in final edited form as: J Allergy Clin Immunol. 2009 Mar;123(3):596–602.e8. doi: 10.1016/j.jaci.2008.12.020

TABLE V.

Association of ARG1h4 haplotype haplotype with asthma within strata of atopy and ambient ozone.

Children’s atopy status	Ambient Ozone Categories	N^*	ARG1h4 haplotype	P-value^‡
Children’s atopy status	Ambient Ozone Categories		OR (95% CI) ^†
Non-atopic	Low	59/723	1.30 (0.57–2.97)	0.008
Non-atopic	High	68/859	0.55 (0.19–1.57)
Atopic	Low	145/399	0.66 (0.31–1.40)
Atopic	High	129/344	0.12 (0.04–0.43)

N represents numbers of children with/without asthma within each atopy and ambient ozone categories.

^†

ORs represent asthma risk associated with per copy of ARG1h4 haplotype within each atopy and ambient ozone categories. The ORs are adjusted for age, sex, ethnicity, parental history of asthma, parent/guardian’s education, in utero exposure to maternal smoking, exposure to secondhand smoke, health insurance coverage, and community of residence.

^‡

P-value for heterogeneity of haplotype effects across categories of atopy/ozone and was obtained from a likelihood ratio test and was based on 3df.