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. Author manuscript; available in PMC: 2010 Aug 2.
Published in final edited form as: Nat Rev Neurosci. 2009 Oct;10(10):724–735. doi: 10.1038/nrn2719

Figure 4.

Figure 4

Control of arealization of the frontal cortex by Fgf expression. A. Patterning centers in the forebrain from REF 141. Fgf expression is in the rostral patterning center (also called commissural plate, CP). B. Fgf expression in the rostral patterning center in coronal sections of an E12.5 mouse telencephalon from REF. 76 C. Transcription factors expressed in the E12.5 rostral telencephalon; arrows show approximate boundaries of their expression in the anlage of the frontal cortex CX: Cortex; LGE: lateral ganglionic eminence; SE: septum. Dotted lines: cortical/subcortical boundary. (Faedo and Rubenstein, unpublished). D. Repression of COUP-TF1 expression by Fgf17 (Fgf17−/− null mutant) (B), Fgf8 (hypomorphic neo/neo mutant) (C). Promotion of COUP-TF1 expression by Fgf15 (Fgf15−/− null mutant) (E). Coronal sections of E12.5 telencephalon from REFS. 76,77.