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. Author manuscript; available in PMC: 2010 Aug 2.
Published in final edited form as: Nat Rev Neurosci. 2009 Oct;10(10):724–735. doi: 10.1038/nrn2719

Figure 5.

Figure 5

The schematic illustration of half of a cross-section through fetal rodent (A) and human (B) forebrains at the peak of corticogenesis at approximately same scale (A′ is an enlargement of the mouse forebrain to render the drawing legible). In rodents (A′), the main source of interneurons is the ganglionic eminence (GE) of the ventral telencephalon, which then migrate tangentially to the neocortex in the dorsal telencephalon. In contrast, interneurons in the human forebrain originate both in the GE as well as locally in the ventricular zone/subventricular zone (VZ/SVZ) of the dorsal telencephalon subjacent to the neocortex. Interneurons originating from the cortical VZ/SVZ and GE express different set of markers. (Figure based on REF. 142 (mouse) and REFS. 101,106 (human).