Skip to main content
. Author manuscript; available in PMC: 2011 Jul 23.
Published in final edited form as: Circ Res. 2010 May 20;107(2):271–282. doi: 10.1161/CIRCRESAHA.110.219899

Figure 3. LDLR+/− mice transgenic for SM-caPTH1R exhibit increased levels of aortic PTH1R protein without improvements in “gdiabesity”h phenotype or alterations in bone turnover.

Figure 3

Figure 3

Figure 3

Figure 3

Panel A, schematic of the SM-caPTH1R expression construct and Acl1-NdeI fragment used to generate transgenic mice. Panel B, immunoreactive PTH1R protein was significantly increased in aortic extracts from SM-caPTH1R;LDLR+/− mice vs. non-transgenic LDLR+/− littermates (n = 4). Panel C, body composition assessed by DXA was unaffected by the SM-caPTH1R transgene (n = 14–16/group; 4 months HFD). Panel D, likewise, serum fasting glucose, cholesterol, triglycerides, and free fatty acids were not improved by the SM-caPTH1R transgene.