Table 1.

Co-evolving residue pairs in HIV-1 CRF01_AE protease.

Residue 1	Residue 2	Probability 1 →2	Probability 2 →1	Posterior probability 1 ↔2
L63‡	I93‡	0.359	0.640	0.999
I54	V82	0.567	0.429	0.997
A71	M89*	0.340	0.654	0.995
L10	I84	0.846	0.146	0.992
P39	Q61	0.734	0.228	0.962
I64	L90	0.520	0.440	0.960
K43	Q61	0.790	0.168	0.958
K43	R57	0.323	0.606	0.930
M46	K55	0.439	0.486	0.925
K69*	I72	0.550	0.372	0.923

^*Residues that differed between the CRF01_AE and subtype B consensus sequences in pro.

^‡Residues found to be under positive selection by the single likelihood ancestor counting [24].