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. Author manuscript; available in PMC: 2010 Aug 2.
Published in final edited form as: Eur J Neurosci. 2008 Nov;28(10):2028–2040. doi: 10.1111/j.1460-9568.2008.06479.x

Fig. 5.

Fig. 5

Concentration-dependent and use-dependent effects of cocaine on sodium currents in VTA GABA neurons in vitro. (Ai) This graph shows the ‘voltage waveform command’ applied to VTA GABA neurons in voltage-clamp mode to elicit TTX-sensitive sodium currents (Aii–iv). (Aii) Control current response, (Aiii) the effect of cocaine (7 μm) after 8 min, and (Aiv) the effect of 0.5 μm TTX showing abolition of sodium currents. (B) Superimposed traces of the first current events (taken from points indicated by filled circles in Aii and iii) and last five current events (taken from point indicated by line on current traces Aii and iii) of the control and cocaine effect. (C) This graph summarizes the dose-dependent effects of cocaine on the first sodium current, the total of all currents and the last 25 currents induced by the voltage waveform command. All concentrations of cocaine significantly reduced the total current and last 25 sodium current events. Only 15 and 50 μm significantly reduced the first current event. *P < 0.05, **P < 0.01 and ***P < 0.001.