Table 1.
Distribution of Variables at Baseline and Outcomes in All Subjects and Subjects Divided into Three CRP Groups
| Variable | C-reactive Protein (CRP) Levels |
||||
|---|---|---|---|---|---|
| Undetectable | Detectable | Elevated | |||
| All subjects |
< 0.5 mg/dL |
0.5-0.7 mg/dL |
≥ 0.8 mg/dL |
||
| N = 227 | N = 80 | N = 81 | N = 66 | ||
| % (#) | % | % | % | p-value | |
| Demographics | |||||
| Female | 62 (141) | 61 | 65 | 59 | 0.719 |
| Have APOE4 allele | 20 (45) | 21 | 23 | 14 | 0.307 |
| Education level | |||||
| ≤ High school graduate | 26 (59) | 20 | 27 | 32 | 0.060 |
| Some college to college graduate |
49 (111) | 44 | 54 | 49 | |
| Post-graduate education | 25 (57) | 36 | 19 | 19 | |
| Lifestyle | |||||
| Smoke | 1 (3) | 3 | 1 | 0 | 0.411 |
| Drink alcohol | 67 (152) | 69 | 69 | 62 | 0.739 |
| Use estrogen (women only) | 6 (14) | 4 | 9 | 6 | 0.422 |
| Medical history | |||||
| 0.041 | |||||
| Hypertension | 51 (116) | 40 | 57 | 59 | * |
| 0.001 | |||||
| Coronary Artery Disease | 14 (32) | 12 | 25 | 5 | * |
| Myocardial Infaction | 14 (31) | 14 | 11 | 17 | 0.639 |
| Atrial fibrillation/arrythmias | 29 (66) | 24 | 31 | 35 | 0.378 |
| Heart Valve Disease | 6 (14) | 5 | 9 | 5 | 0.517 |
| Congestive Heart Failure | 8 (18) | 4 | 9 | 12 | 0.190 |
| Stroke | 7 (17) | 10 | 7 | 5 | 0.447 |
| Transient Ischemic Attack | 15 (33) | 13 | 12 | 22 | 0.203 |
| High Cholesterol | 29 (66) | 26 | 34 | 30 | 0.534 |
| Diabetes | 4 (10) | 4 | 6 | 3 | 0.618 |
| Rheumatoid Arthritis | 8 (18) | 11 | 4 | 11 | 0.202 |
| Osteoarthritis | 41 (88) | 41 | 42 | 40 | 0.982 |
| Cognitive diagnosis | |||||
| Normal | 56 (127) | 54 | 57 | 58 | 0.882 |
| CIND | 44 (100) | 46 | 43 | 42 | |
| Outcomes | |||||
| All-cause Dementia | 36 (82) | 39 | 32 | 38 | 0.639 |
| All-cause Mortality | 48 (108) | 38 | 53 | 53 | 0.081 |
p < 0.05 level
APOE4 = apolipoprotein E4; CIND = Cognitively Impaired Not Demented