Table 2.

Hazard Ratios^* for All-Cause Dementia and All-Cause Mortality

		Undetectable	Detectable		Elevated
	N	(N = 80)	(N = 81)	p-value	(N = 66)	p-value
All-Cause Dementia
All Subjects †
Model 1	227	1.0	1.1 (0.6 - 1.8)	0.848	1.1 (0.6 - 1.9)	0.811
Model 2	212	1.0	1.2 (0.6 - 2.1)	0.629	1.0 (0.5 - 1.8)	0.916
Gender
Men
Model 1	86	1.0	0.9 (0.3 - 2.3)	0.777	0.9 (0.4 - 2.2)	0.812
Model 2	78	1.0	0.7 (0.2 - 2.3)	0.581	0.7 (0.2 - 2.0)	0.523
Women
Model 1	141	1.0	1.1 (0.6 - 2.2)	0.734	1.2 (0.6 - 2.4)	0.654
Model 2	134	1.0	1.4 (0.7 - 3.0)	0.360	1.2 (0.5 - 2.8)	0.652
APOE genotype
APOE4-
Model 1	182	1.0	0.9 (0.5 - 1.6)	0.656	0.9 (0.5 - 1.8)	0.864
Model 2	167	1.0	1.0 (0.5 - 2.1)	0.903	0.9 (0.4 - 1.8)	0.711
APOE4+
Model 1	45	1.0	1.6 (0.5 - 4.9)	0.415	1.9 (0.5 - 6.5)	0.319
Model 2	45	1.0	4.5 (0.9 - 23.3)	0.074	2.7 (0.6 - 12.2)	0.209
All-Cause Mortality
All Subjects †
Model 1	227	1.0	1.7 (1.1 - 2.8)	0.025	1.4 (0.9 - 2.4)	0.187
Model 2	212	1.0	1.7 (1.0 - 2.9)	0.042	1.3 (0.7 - 2.2)	0.384
Gender
Men
Model 1	86	1.0	1.4 (0.7 - 2.9)	0.311	1.0 (0.5 - 2.2)	0.952
Model 2	78	1.0	1.5 (0.7 - 3.6)	0.331	0.9 (0.4 - 2.1)	0.720
Women
Model 1	141	1.0	2.1 (1.1 - 4.2)	0.034	2.1 (1.0 - 4.3)	0.050
Model 2	134	1.0	2.1 (1.0 - 4.5)	0.057	1.7 (0.8 - 4.0)	0.192
APOE genotype
APOE4-
Model 1	182	1.0	1.7 (1.0 - 2.9)	0.055	1.3 (0.7 - 2.2)	0.419
Model 2	167	1.0	1.6 (0.9 - 2.9)	0.106	1.1 (0.6 - 2.1)	0.700
APOE4+
Model 1	45	1.0	2.1 (0.7 - 6.5)	0.212	1.9 (0.5 - 7.2)	0.339
Model 2	45	1.0	5.6 (1.0 - 30.7)	0.046	2.6 (0.4 - 18.7)	0.345

^*Hazard ratios (HR), 95% confidence intervals (CI), and p-values were computed using Cox regression. Model 1 was adjusted for age. Model 2 was adjusted for age, gender, education, apolipoprotein E4 (APOE4) status, and medical history of hypertension, coronary artery disease, congestive heart failure, and transient ischemic attack. The number of subjects (N) shown is the total number included in that analysis.

^†In all subjects, age was significant in both models, and history of CHF was significant in Model 2.