Table 2.
Biochemical changes in response to 12 months of testosterone therapy in female-to-male transsexuals, including changes in lipid profile and markers of insulin resistance. Mean ± SEM, N = 12 unless specified.
| Prior to Testosterone | 12 months | P-value | |
|---|---|---|---|
| Body Mass Index (BMI) (kg/m2) | 27.5 ± 5.2 | 27.6 ± 3.9 | .47 |
|
| |||
| Mean Arterial Pressure (MAP (mm Hg) | 87 ± 14 | 91 ± 16 | .16 |
|
| |||
| Serum Glutamic Oxaloacetic Transaminase (SGOT) (IU/L) | 21 ± 5 | 25 ± 7 | .22 |
|
| |||
| Serum Glutamate Pyruvate Transaminase (SGPT) (IU/L) | 19 ± 7 | 24 ± 10 | .22 |
|
| |||
| Serum Total Testosterone (nmol/L) | 3.4 ± 3.0 | 34.6 ± 8.5 | <.001 |
|
| |||
| Hematocrit (%) | 40 ± 2 | 45 ± 5 | <.001 |
|
| |||
| Platelets (×1000/μL) | 282 ± 44 | 266 ± 38 | .21 |
|
| |||
| High Density Lipoprotein (HDL) (mg/dL) | 52 ± 11 | 40 ± 7 | <.001 |
|
| |||
| Low Density Lipoprotein (LDL) (mg/dL) | 113 ± 22 | 121 ± 29 | .32 |
|
| |||
| Total Cholesterol (mg/dL) | 184 ± 26 | 181 ± 34 | .77 |
|
| |||
| Triglycerides (mg/dL) | 92 ± 72 | 94 ± 41 | .91 |
|
| |||
| Leptin (ng/dL) | 31.2 ± 29.5 | 19.1 ± 17.5 | .18 |
|
| |||
| Resistin (ng/dL) | 10.3 ± 2.1 | 9.6 ± 2.2 | .68 |
|
| |||
| Fasting glucose (mg/dL) | 86 ± 12 | 83 ± 11 | .43 |