Table 4.

Odds ratios (OR) and 95% confidence intervals among all subjects for risk factors associated with Minimally Clinically Important Improvement (MCII) in WOMAC^* physical function mutually adjusted for for other factors^†, with higher OR representing greater likelihood of MCII.

		n	MCII Definitions
			MCII 26%‡	MCII 17%§	MCII Tertile**
ROA ††	Absent	756	1.0 (reference)	1.0 (reference)	1.0 (reference)
	Present	1045	0.6 [0.4,0.7]	0.6 [0.5,0.7]	0.5 [0.4,0.6]
Walking Speed [meters/second (m/s)]	OR of MCII per 1.0 m/s	1801	1.9 [1.0,3.4]	1.9 [1.1,3.3]	2.0 [1.0,3.9]
	Number of subjects included in logistic models		1768	1768	1768
	Hosmer and Lemeshow Test (p-value)	8 degrees of freedom	0.08	0.61	0.32

^*WOMAC = Western Ontario McMaster Universities Osteoarthritis Index

^†Mutually adjusted for age, gender, education, comorbidities, body mass index, knee pain, knee strength, depressive symptoms, physical activity, and medication usage at baseline.

^‡26% decrease in WOMAC physical function to reach meaningful clinically important improvement

^§17% decrease in WOMAC physical function to reach meaningful clinically important improvement

^**3.6, 8.0, and 13.9 out of 68 for those in low, medium, and high baseline WOMAC physical function tertiles, respectively

^††ROA= Radiographic knee osteoarthritis