Table 5.

Odds ratios (OR) and 95% confidence intervals among persons with ROA at baseline for risk factors associated with Minimally Clinically Important Improvement (MCII) in WOMAC^* physical function mutually adjusted for other factors^†, with higher OR representing greater likelihood of MCII.

	Mean (sd)	n	MCII Definitions
			MCII 26%‡	MCII 17%§	MCII Tertile**
Knee strength [Newton-Meters]
Low	27.1 (9.7)	316	1.0 (reference)	1.0 (reference)	1.0 (reference)
Medium	54.75 (8.1)	313	1.5 [1.0,2.2]	1.4 [1.0,2.0]	1.6 [1.0,2.6]
High	104.0 (28.3)	315	1.9 [1.1,3.0]	1.7 [1.1,2.7]	2.2 [1.2,4.0]
	Number of subjects included in logistic models		935	935	935
	Hosmer and Lemeshow Test (p-value)	8 degrees of freedom	0.18	0.31	0.37

^*WOMAC = Western Ontario McMaster Universities Osteoarthritis Index

^†Mutually adjusted for age, gender, education, comorbidities, body mass index, knee pain, depressive symptoms, physical activity, ROA in one or both knees, and medication usage at baseline.

^‡26% decrease in WOMAC physical function to reach meaningful clinically important improvement

^§17% decrease in WOMAC physical function to reach meaningful clinically important improvement

^**3.6, 8.0, and 13.9 out of 68 for those in low, medium, and high baseline WOMAC physical function tertiles, respectively