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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: J Neurochem. 2010 Feb 1;113(3):649–660. doi: 10.1111/j.1471-4159.2010.06622.x

Figure 4.

Figure 4

NA neuroprotection is mediated by B-adrenergic receptors. A) Bar graph shows cell death after 48 hours of 10 μM Aβ25–35 exposure following pretreatment of hNT neurons with 10 μM NA or adrenoceptor agonists isoproterenol (ISO, β), salmeterol (SAL, β2), cirazoline (CRZ, α1), or UK 14,304 (UK, α2) [all doses 10μM except ISO (100 μM)]. *, p < 0.001 vs. CTL; **, p < 0.001 vs. Aβ. B) Bar graph shows cell death after 48 hours of Aβ25–35 alone, pretreated with NA, or co-treated with NA following pretreatment with adrenoceptor antagonists CGP 20712 (CGP, β1), ICI 118, 551(ICI, β2), prazosin (PRZ, α1), or yohimbine (YHB, α2) (all doses 10 μM). *, p < 0.001 vs. CTL; **, p < 0.001 vs. Aβ; #, p < 0.05 vs., Aβ; n = 8/treatment group in 3 independent experiments for each assay.