Fig. 10.

A diagram of the proposed inhibition of transport proteins by sulindac and metabolites in hepatocytes. Sulindac and metabolites inhibited multiple hepatic transport proteins including Ntcp/NTCP, Oatps/OATPs, Bsep, Bcrp, and MRP2 in rat and/or human hepatocytes. Inhibition of transport proteins by sulindac and metabolites are depicted by thick lines; dashed lines indicate the marginal inhibition profiles of transport proteins by sulindac and metabolites. Impaired function of multiple hepatic transporters by sulindac/metabolites may disturb bile acid homeostasis and affect hepatobiliary disposition of coadministered drugs. Thus, when sulindac is coadministered with other drugs/xenobiotics, the possibility of drug interactions should be considered. N.D., not determined; N.S., not significant.