Fig. 2.
Effect of sulindac and metabolites on hepatobiliary disposition of TC in rat SCH. Accumulation of [3H]TC (1 μM, 100 nCi/ml, 10 min) in cells + bile (black bars) and cells (white bars) was measured in the presence of increasing concentrations (1–100 μM) of sulindac (A), S-sulfone (B), or S-sulfide (C) in rat SCH. BEI and in vitro Clbiliary of TC were calculated as described under Materials and Methods. Data are presented as the mean ± S.E.M (n = 3–4 livers in triplicate); ∗, statistically different from vehicle control (CTL) by one-way ANOVA with Bonferroni's post hoc test.