Fig. 4.
Effect of sulindac and metabolites on hepatobiliary disposition of NF in rat SCH. Accumulation of NF (5 μM, 10 min) in cells + bile (black bars) and cells (white bars) was measured in the presence of 100 μM sulindac, S-sulfone, or S-sulfide in rat SCH. BEI and in vitro Clbiliary of NF were calculated as described under Materials and Methods. Data are presented as the mean ± S.E.M (n = 3 livers in triplicate); ∗, statistically different from vehicle control (CTL) by one-way ANOVA with Bonferroni's post hoc test.