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Effect of sulindac and metabolites on hepatobiliary disposition of E217G in human SCH. Accumulation of [3H]E217G (1 μM, 100 nCi/ml, 10 min) in cells + bile (solid bars) and cells (empty bars) was measured in the presence of 100 μM sulindac, S-sulfone, or S-sulfide in human SCH. BEI and in vitro Clbiliary of E217G were calculated as described under Materials and Methods. Bars and error bars denote mean ± half the range from n = 2 livers in duplicate.
