TABLE 1.
Effect of 5A-POPC treatment of plasma chemistry profile and body weight
Four-month-old apoE-KO mice (n = 8) were injected intravenously with 5A-POPC (30 mg/kg) every Monday, Wednesday, and Friday for 13 weeks and weighed and then plasma was analyzed for the indicated parameters. Results represent the mean ± 1 S.D. of eight replicates.
| Parameter | POPC | 5A-POPC | p Value |
|---|---|---|---|
| Aspartate aminotransferase (U/l) | 85 ± 10 | 81 ± 13 | 0.8 |
| Alanine aminotransferase (U/l) | 38 ± 5 | 39 ± 2 | 0.9 |
| LDH (U/l) | 252 ± 18 | 274 ± 39 | 0.62 |
| Creatinine (mg/dl) | 0.14 ± 0.02 | 0.11 ± 0.03 | 0.3 |
| Blood urea nitrogen (mg/dl) | 19 ± 0.5 | 19 ± 1 | 0.83 |
| Glucose (mg/dl) | 135 ± 2 | 144 ± 9 | 0.48 |
| Weight (g) | 26 ± 2 | 24 ± 0.5 | 0.2 |