Effects of sEH KO or inhibition on blood glucose levels in STZ mice. Weekly fasting blood glucose levels of Ephx2(+/+) + STZ (n = 10), Ephx2(−/−) + STZ (n = 11), Ephx2(+/+) + STZ + t-AUCB (10 mg/l in drinking water; n = 5), Ephx2(+/+) + vehicle (n = 5), and Ephx2(−/−) + vehicle (n = 5) after STZ treatment. ∗, P < 0.05 versus Ephx2(+/+) + vehicle; #, P < 0.05 versus Ephx2(+/+) + STZ.