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A, Intraperitoneal insulin tolerance tests in Ephx2(+/+) and Ephx2(−/−) mice. After 6-h fast, mice (n = 4) from each group were injected with 1 U/kg human insulin i.p. (time = 0). Blood glucose concentrations were measured before and at 10, 30, and 60 min after insulin administration. B, fed (n = 5) and fasted (n = 4) glucagon levels in Ephx2(+/+) and Ephx2(−/−) mice. Glucagon levels in Ephx2(−/−) mice were indistinguishable from those of their littermate control, Ephx2(+/+) mice.
