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Glucose-induced changes in [Ca2+]i in Ephx2(−/−) and Ephx2(+/+) cells. A, representative Ca2+ traces obtained from individual Ephx2(−/−) (n = 19) and Ephx2(+/+) (n = 16) islet cells in response to 3 mM glucose, 25 mM glucose, or 30 mM KCl plus 250 μM diazoxide plus 3 mM glucose. B, quantitative summary of the [Ca2+]i response to different stimulators. ∗∗, P < 0.01 versus Ephx2(+/+) mice. Cells representing at least five different mice from each genotype were analyzed.
