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. 2010 Aug;334(2):430–438. doi: 10.1124/jpet.110.167544

Fig. 8.

Fig. 8.

A, in Ephx2(−/−) mice treated with vehicle, pancreases showed no apoptotic cell. In Ephx2(+/+) mice treated with vehicle, pancreases showed no apoptotic cell. On day 14 after STZ treatment, representative pancreatic photomicrography showed two apoptotic cells in islet of Ephx2(−/−) mice. On day 14 after STZ treatment, representative pancreatic photomicrography showed six apoptotic cells in islet of Ephx2(+/+) mice. B, quantification analysis of TUNEL assay showed that islet cell apoptosis in the STZ-Ephx2(+/+) group is significantly higher than in the STZ-Ephx2(−/−) group; n = 4. ∗, P < 0.05 versus STZ-Ephx2(+/+) mice.