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Potential mechanism of action involved in the reduction of insulin resistance and inflammation in skeletal muscle cells following PPARβ/δ activation by GW501516. ACC-2, acetyl-CoA carboxylase 2; AMPK, AMP-activated protein kinase; CPT-1, carnitine palmitoyltransferase-1; DAG, diacylglycerol; IKKβ, IκB kinase β; IL-6, interleukin 6; IRS-1, Insulin Receptor Substrate 1; NF-κB, Nuclear Factor-κB; PDK-4, pyruvate dehydrogenase kinase 4; PKCθ, protein kinase Cθ.
