Table 2.

Estimated global burden of congenital syphilis cases.

Proportion of seropositive women with:	Watson-Jones [8, 11]	Schulz [12]	WHO [13]
Untreated syphilis	95%*	100%	100%
High serologic titer (≥1 : 8)	73%	—	—
Adverse pregnancy outcome due to syphilis**	49%	65%	75%
Global Annual No. of Congenital Syphilis Cases	692,100	1,323,900	1,527,600

Note that all assumptions based on WHO estimate of 2,036,753 pregnant women with syphilis [9].

*not included in the original Watson-Jones model; **includes late fetal loss, perinatal death, prematurity/low birth weight, neonatal infection.