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. Author manuscript; available in PMC: 2011 Aug 6.

Published in final edited form as: Brain Res. 2010 Jun 9;1347:11–18. doi: 10.1016/j.brainres.2010.05.094

(A) Lack of effect of amastatin and bestatin (both 10 μM) on L-[³H]tyrosine uptake clearance (expressed as % of control) in neonatal astrocytes from Pept2^-/- mice. Values are means±SE, n = 3. (B) Time course of L-[³H]tyrosine accumulation (in the presence of 1 μM tyrosine) in neonatal astrocytes from Pept2^-/- mice. The initial uptake rate (0.5 min) was 190±2 pmol/mg/min and uptake plateaued at 423±10 pmol/mg. At equilibrium, efflux = influx and, therefore, the efflux rate can be estimated as 45%/min. Values are means±SE, n = 3.

(A) Lack of effect of amastatin and bestatin (both 10 μM) on L-[³H]tyrosine uptake clearance (expressed as % of control) in neonatal astrocytes from Pept2^-/- mice. Values are means±SE, n = 3. (B) Time course of L-[³H]tyrosine accumulation (in the presence of 1 μM tyrosine) in neonatal astrocytes from Pept2^-/- mice. The initial uptake rate (0.5 min) was 190±2 pmol/mg/min and uptake plateaued at 423±10 pmol/mg. At equilibrium, efflux = influx and, therefore, the efflux rate can be estimated as 45%/min. Values are means±SE, n = 3.