TABLE II.

EFFECTS OF PARGYLINE OR RO 4-4602 ON THE CONCENTRATIONS OF DA, DOPAC, HVA, 5-HTP, 5-HT AND 5-HIAA IN THE STRIATUM, OLFACTORY TUBERCLE AND NUCLEUS ACCUMBENS

Treatment	Protein (ng/mg)
	DA	DOPAC	HVA	5-HTP	5-HT	5-HIAA
	Striatum
Saline	90.3 ± 6.7	17.2 ±1.2	9.3 ±0.9	–	4.6 ±0.5	6.4 ± 0.6
Pargyline	112.0 ±6.5*	0.58 ±0.12*	1.4 ± 0.08*	–	8.3 ± 0.8*	4.1 ± 0.4*
RO 4-4602	57.4 ± 5.3*	16.1 ± 4.9	8.2 ±0.4	6.0 ± 0.5	2.8 ± 0.4*	6.3 ± 0.7
	Olfactory tubercle
Saline	41.3 ±4.0	7.8 ±1.0	3.1 ±0.8	–	10.1 ± 1.1	5.3 ± 0.8
Pargyline	55.9 ± 6.8*	0.39 ±0.01*	0.26 ± 0.04*	–	15.7 ± 0.5*	1.4 ± 0.2*
RO 4-4602	29.5 ± 3.9*	5.8 ± 0.8	2.2 ±0.1	9.9 ± 1.0	6.3 ± 0.9*	4.2 ± 0.3
	Nucleus accumbens
Saline	59.3 ± 5.0	15.4 ± 1.0	5.7 ±0.6	–	5.9 ± 0.9	5.5 ± 0.6
Pargyline	96.4 ± 2.5*	1.1 ± 0.2*	1.5 ± 0.09*	–	9.0 ± 0.9*	2.4 ± 0.2*
RO 4-4602	64.6 ± 7.2	13.8 ± 1.2	5.0 ±0.8	10.0 ± 1.6	5.9 ± 0.6	4.9 ± 1.2

Animals were sacrificed 45 min after saline (1 ml/kg), pargyline (75 mg/kg) or RO 4-4602 (750 mg/kg). Brain regions were dissected and the samples assayed as described in Methods. Values represent means ± S.E.M. for 3 or 4 determinations.

^*Indicates values different from saline-injected controls at p < 0.05.