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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Tetrahedron Lett. 2010 Sep 1;51(35):4595–4598. doi: 10.1016/j.tetlet.2010.06.074

Table 3.

Synthesis of N,N-diethyl-2-(2-(4-methoxyphenyl)-5,7-dimethylpyrazolo[l,5-a] pynmidin-3-yl) acetamide (5, DPA-713).

Entry MAOS Reaction Conditions Temperature Time Yielda
16a No EtOH RT 4 h 44%
26b No EtOH Reflux 12 h 93%
3 Yes EtOH 160 °C 30 min 91%
a

Isolated yield. See reference.6a,6b