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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Tetrahedron Lett. 2010 Sep 1;51(35):4595–4598. doi: 10.1016/j.tetlet.2010.06.074

Table 5.

Synthesis of N,Ndiethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[l,5-a]pyrimidin-3-yl)acetamide (7, DPA-714).

Entry MAOS Reaction Conditions Temperature Time Yielda
16c No NaH, THF RT 16 h 80%
26d No NaH, THF RT 16 h 58%
3 Yes NaH, THF 120 °C 15 min 79%
a

Isolated yield. See reference.6c,6d