TABLE 1. Effect of TRH on ethanol-induced sleep in mice.

TRH was administered intracisternally 10 minutes after injection of 4.7 g/kg of ethanol. TRH administered intraperitoneally or orally was given at the time of ethanol administration. Linear correlation coefficients for sleep time over log dose of TRH: Intracisternal: r = 0.976, n = 8, P < .001. Intraperitoneal: r = 0.844, n = 5, P > .05. Oral: r = 0.686, n = 5, P > .1

Treatment	N	Sleeping time
		min ± S.E.M.
A. Intracisternal TRH
Saline	24	93.7 ± 5.93
0.01 μg	9	72.5 ± 11.57
0.05 μg	10	67.4 ± 7.41
0.2 μg	17	65.2 ± 7.99a
1.0 μg	17	62.7 ± 7.96b
5.0 μg	15	55.6 ± 5.78e
10.0 μg	18	51.6 ± 4.74e
15.0 μg	15	48.3 ± 5.90e
20.0 μg	14	51.9 ± 4.99e
B. Intraperitoneal TRH
Saline	19	79.5 ± 6.58
1 mg/kg	9	68.8 ± 12.14
3 mg/kg	10	58.0 ± 7.20
10 mg/kg	10	49.5 ± 5.30c
30 mg/kg	10	56.6 ± 5.02a
100 mg/kg	10	46.2 ± 2.98e
C. Oral TRH
Saline	31	68.6 ± 5.66
1 mg/kg	10	58.8 ± 7.33
3 mg/kg	10	75.3 ± 4.33
10 mg/kg	27	50.3 ± 4.01a
30 mg/kg	31	49.4 ± 2.83c
100 mg/kg	30	46.4 ± 3.18d

When compared with saline:

^aP < .05.

^bP < .02.

^cP < .01.

^dP < .005.

^eP < .001.