TABLE 7. Effects of intracisternally administered atropine methyl nitrate on reduction of ethanol-induced sleep by TRH.
| Treatment | Dose | Sleeping Time |
|
|---|---|---|---|
| Saline Pretreat- menta |
Atropine Methyl Nitrate Pretreat- menta |
||
| min ± S.E.M. | |||
| Saline | 109.4 ± 8.0 (19) | 110.4 ± 6.9 (28) | |
| TRH | 10 mg/kg | 69.3 ± 4.3d (20) | 117.8 ± 5.4 (19) |
| TRH | 30 mg/kg | 73.1 ± 3.2d (24) | 90.7 ± 5.0 (10) |
| TRH | 100 mg/kg | 80.1 ± 5.1b (24) | 97.8 ± 3.2 (10) |
| TRH | 5 μg (i.c.) | 76.5 ± 5.1c (10) | 101.3 ± 11.1 (9) |
a
Atropine methyl nitrate (10 μg) and saline pretreatments were administered intracisternally (i.c.) 10 minutes after ethanol, and 30 seconds before TRH. Number of animals per group appear in parentheses.
When compared with i.p. saline treatment:
b
P < .025.
c
P < .01.
d
P < .001.