Table 1.
Optimal model parameters
| Parameter, kj | Description | Value |
|---|---|---|
| a1 (h-1) | Max. rate: WC-1* upregulated frq transcription | 8.3450 |
| a2 (h-1) | Max. rate: WC-1 upregulated frq transcription | 3.7925 |
| a3 (h-1) | FRQ translation rate | 0.3154 |
| a4 (h-1) | Basal wc-1 transcription rate | 0.6787 |
| a5 (h-1) | Max. rate: WC-1* upregulated wc-1 transcription | 10.0718 |
| a6 (h-1) | Basal WC-1 translation rate | 6.6644 |
| a7 (nM-1h-1) | FRQ upregulated WC-1 translation rate | 2.4695 |
| b1 (nM-1) | Michaelis constant: repression of WC-1* upregulated frq transcription | 4.1472 |
| b2 (nM) | Michaelis constant: WC-1* upregulated frq transcription | 0.1560 |
| b3 (nM-1) | Michaelis constant: repression of WC-1 upregulated frq transcription | 0.7149 |
| b4 (nM) | Michaelis constant: WC-1 upregulated frq transcription | 2.9415 |
| b5 (nM) | Michaelis constant: frq mRNA degradation | 4.1075 |
| b6 (nM) | Michaelis constant: degradation of active FRQ | 0.4715 |
| b7 (nM) | Michaelis constant: WC-1* upregulated wc-1 transcription | 3.5676 |
| b8 (nM) | Michaelis constant: wc-1 mRNA degradation | 0.5805 |
| b9 (nM) | Michaelis constant: degradation of active WC-1 | 7.0233 |
| b10 (nM) | Michaelis constant: degradation of WC-1* | 0.8218 |
| d1 (h-1) | Max. rate: frq mRNA degradation | 7.4608 |
| d2 (h-1) | Max. rate: degradation of active FRQ | 0.4405 |
| d3 (h-1) | Max. rate: wc-1 mRNA degradation | 2.1710 |
| d4 (h-1) | Max. rate: degradation of active WC-1 | 3.0883 |
| d5 (h-1) | Max. rate: degradation of WC-1* | 23.3120 |
| f1 (h-1) | Delay parameter: FRQ → active FRQ conversion | 0.1962 |
| f2 (h-1) | Delay parameter: WC-1 → active WC-1 conversion | 0.1317 |
| γ1 (h-1) | Loss rate: FRQ → active FRQ conversion (deg. rate of intermediates) | 0.0422 |
| γ2 (h-1) | Loss rate: WC-1 → active WC-1 conversion (deg. rate of intermediates) | 0.0244 |
| r1 (h-1) | Rate of active WC-1 → WC-1* conversion | 5.1759 |
| r2 (h-1) | Rate of WC-1* → active WC-1 conversion | 5.0326 |
| n | Hill coefficient: WC-1* upregulated frq transcription | 1.0168 |
| m | Hill coefficient: WC-1 upregulated frq transcription | 2.8134 |
| k | Hill coefficient: WC-1* upregulated wc-1 mRNA transcription | 1.4135 |
| g | Hill coefficient: repression of WC-1* upregulated frq transcription | 1.2730 |
| h | Hill coefficient: repression of WC-1 upregulated frq transcription | 3.6978 |
Parameter values yielding the optimal value of the cost function used to fit the model to experimental data. WC-1* denotes light-induced active WC-1.