Figure 7.
Significantly over-represented network motifs in HIV-host protein interaction network. Black nodes are HIV proteins and white nodes are human proteins. Interactions can either be activations/up-regulations (+), inhibitions/down-regulations (-), activation/inhibition/regulation (±), or both (arrow without sign). Nreal is the number of specific motifs found. Nrand ± SD is the average number and standard deviation of the motif found in one thousand randomized networks. Pvalue is the probability that Nreal or more motifs are found in the randomized networks. Zscore is the number of standard deviations Nrand differs from Nreal. Network motifs were classified as significant when Pvalue < 0.02 and Zscore > 2.