Table 3.

Mean values of centrality measures on HDFs and on proteins of the whole human protein interaction network, with standard deviations between brackets.

μ (σ)	HDF network	total human network	$P_{value}^{ks}$(HDF > total)
degree	16 (25)	6 (11)	2.42·10-97
betweenness	63·103 (19·104)	17·103 (79·103)	9.22·10-63
eigenv. centr.	0.049 (0.10)	0.013 (0.04)	3.08·10-87

$P_{value}^{ks}$ is calculated from a one-sided Kolmogorov-Smirnov test with alternative hypothesis: HDF network > total human network regarding degree, betweenness and eigenvector centrality. In the HDF network each node has approximately three times more connections (16 in HDF vs 6 in the total human network), four times higher betweenness (63·10³ in HDF vs 17·10³ in human) and a four times higher eigenvector centrality score (0,049 in HDF vs 0,013 in human). The significant higher centrality of the HDF sub-network shows that it takes on a central position within the total human protein interaction network.