Table 5.
Top one percent of proteins that have the highest score from the betweenness centrality metric.
| Name | Definition | Betweenness Score |
|---|---|---|
| TP53 [GenBank:NP_000537.3] | tumor protein p53 | 44050 |
| UBC [GenBank:NP_066289.2] | ubiquitin C | 36458 |
| GRB2 [GenBank:NP_002077.1] | growth factor receptor-bound protein 2 isoform 1 | 22792 |
| BRCA1 [GenBank:NP_009225.1] | breast cancer 1, early onset isoform 1 | 21622 |
| SRC [GenBank:NP_005408.1] | proto-oncogene tyrosine-protein kinase | 21568 |
| EGFR [GenBank:NP_005219.2 ] | epidermal growth factor receptor isoform a | 20472 |
| STAT3 [GenBank:NP_644805.1] | signal transducer and activator of transcription 3 isoform 1 | 18503 |
| ESR1 [GenBank:NP_000116.2] | estrogen receptor 1 | 18424 |
| RB1 [GenBank:NP_000312.2] | retinoblastoma 1 | 16777 |
| PIK3R1 [GenBank:NP_852664.1] | phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 isoform 1 | 16048 |
| POLR2A [GenBank:NP_000928.1] | DNA directed RNA polymerase II polypeptide A | 15896 |
| MYC [GenBank:NP_002458.2] | myc proto-oncogene protein | 15608 |
| SP1 [GenBank:NP_612482.2] | Sp1 transcription factor | 14620 |
| RELA [GenBank:NP_068810.2] | v-rel reticuloendotheliosis viral oncogene homolog A | 14114 |
| SHC1 [GenBank:NP_003020.2] | Src homology 2 domain containing transforming protein 1 isoform p52Shc | 14011 |