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Time-course effect of B1R antagonists administered in the periphery (A) or intrathecally (B) on blood glucose concentration in control and 4-day STZ-diabetic rats. Data are the mean ± S.E.M. of 5 rats in each group. Statistical comparison to control (*) or untreated (0 h) STZ-treated rats (+) is indicated by + P < 0.05, ***P < 0.001.
