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Time-course of the inhibitory effect of B1R antagonists administered in the periphery (A, C) or intrathecally (B, D) on paw withdrawal response frequency (%) to cold stimulation in control and 4-day STZ-diabetic rats. All treatments were given at time 0 h. Data represent the mean ± S.E.M. of 4 to 12 rats in each group. Statistical comparison to control + vehicle (*) and STZ + vehicle (+) is indicated by ++P < 0.01; *** +++P < 0.001.
