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Time-course of the inhibitory effect of fluorocitrate (A) and minocycline (B) on paw withdrawal response frequency (%) to cold stimulation in control and 4-day STZ-diabetic rats. All treatments were given at time 0 h. Data are the mean ± S.E.M. of 4 rats in each group. Statistical comparison to control + vehicle (*) and STZ + vehicle (+) is indicated by ++P < 0.01; +++ ***P < 0.001.
