Table 3.

Comparison of toxicities between wild type and variant allele groups for VEGFR2 SNPs

Toxicity grade ≥2 N (%*)	VEGFR2 H472Q			VEGFR2 V297I
	wt allele	var allele	p-value†	Wt allele	var allele	p-value†
HT	22 (21.4)	26 (38.8)	0.0154	38 (29.0)	12 (30.8)	0.84
HFSR	16 (15.5)	22 (32.8)	0.0136	28 (21.4)	10 (25.6)	0.66
Rash:desquamation	17 (25.0)	13 (28.9)	0.67	23 (27.7)	9 (30.0)	0.82
Diarrhea	14 (20.6)	7 (15.6)	0.62	19 (22.9)	3 (10.0)	0.18
Fatigue	12 (17.7)	6 (13.3)	0.61	14 (16.9)	4 (13.3)	0.78

*% of total patients in that group,^†p-values are based on Fisher's exact test. wt: wild-type, var: variant.