Table 1.

Clinical review for patients with adverse normal tissue reactions to radiotherapy

Patient	Cancer	Sex	ATM%	Age	Reaction	Clinical features
1	Prostate	M	69	64	A	RTOG4 - treatment terminated at 28 Gy
2	Prostate	M	80	72	L	RTOG3 - Proctitis
3	Prostate	M	90	69	L	RTOG3 - Proctitis
4	Prostate	M	82	71	L	RTOG3 - Proctitis
5	Prostate	M	79	60	L	RTOG3 - Cystitis
6	Prostate	M	80	65	L	RTOG3 - Proctitis
7	Cervix	F	71	36	L	RTOG3 - Urethral stricture
8	Cervix	F	81	47	L	RTOG3
9	Breast	F	80	51	A	RTOG3 - Moist desquamation
10*¥∞	Breast	F	35	64	A&L	RTOG4 - Familial Treatment terminated at 20 Gy
11*£¥	Breast	F	45	54	A&L	RTOG3 - Moist desquamation; skin atrophy/pigment
12	Breast	F	82	57	L	RTOG3 - Familial
13*∞£¥	Breast	F	8	50	L	RTOG4 - Familial, skin atrophy & fibrosis, necrosis
14	Breast	F	77	41	L	RTOG3 - Fibrosis (skin, subcutaneous tissue & breast)
15	Breast	F	66	71	L	RTOG4 - Familial
16*£	Breast	F	30	77	L	RTOG4
17	Breast	F	64	47	L	RTOG3
18	Breast	F	88	58	L	RTOG3
19	Breast	F	69	62	L	RTOG3
20	Breast	F	66	70	L	RTOG3

ATM% ~ percentage of ATM protein compared with the highest ATM expresser; * ~ low level of ATM protein < 50% cut-off;

A ~ severe acute reaction; L ~ severe late reaction; ¥ ~ Intermediate ICA count; ∞ ~ ATM mutation(s); £ ~ reduced ATM kinase activity.