Skip to main content
. 2010 Jun 17;3:15. doi: 10.1186/1757-2215-3-15

Figure 6.

Figure 6

Inhibition of apoptotic signal in cisplatin resistant tumor cells. More than one mechanism is usually observed in resistant cells, and this contributes to the multi-factorial nature of cisplatin resistance. CCR9-dependent anti-apoptotic signalling in OvCa cells involves the PI3K/Akt cascade and phosphorylation of its downstream mediators, GSK-3β and FKHR.