Figure 1. Receptor tyrosine kinase families.

Human receptor tyrosine kinases (RTKs) contain 20 subfamilies, shown here schematically with the family members listed beneath each receptor. Structural domains in the extracellular regions, identified by structure determination or sequence analysis, are marked according to the key presented in Supplementary Figure 1, where all 58 RTKs in the human proteome are listed. The intracellular domains are shown as red rectangles.