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. Author manuscript; available in PMC: 2011 Jun 25.
Published in final edited form as: Cell. 2010 Jun 25;141(7):1117–1134. doi: 10.1016/j.cell.2010.06.011

Table 2. Protein modules that mediate intracellular signaling pathways downstream of RTKs and the targets they recognize.

(Li, 2005; Schlessinger and Lemmon, 2003; Seet et al., 2006)

Receptor Tyrosine Kinase Module Targeta
SH2 pYXXX
PTB NPXpY peptides
FHA pTXXD
14-3-3 SXpSXP
SH3 PXXP
WW PXPX
CH F-actin
LIM Protein-protein
SAM Homotypic oligomerization
PDZ C-terminal valine
FERM Membrane and cytoskeleton
PX Phosphoinositides
C1 Membrane
C2 Membrane and calcium
PH Phosphoinositides
FYVE PtdIns3P
UIM Ubiquitin
UBA Ubiquitin
a

Protein sequence motifs are shown in bold.