Figure 2.

Classification of inflammatory molecule responses to repeated LPS stimulation. From the array data described in Figure 1, the ratio of LPS/LPS to 0/LPS was calculated for each inflammatory molecule. Classifications of inflammatory molecule production caused by repeated stimulation with LPS were defined as follows: "tolerance" was a ratio of <0.5 (>50% reduction), "sensitization" was a ratio of >1.5 (>50% increase), and "no change" indicates a ratio between 0.5 and 1.5. The center circle represents the distribution of molecules in the absence of lithium in the "tolerance", "sensitization" and "no change" groups. Each of these three groups was subclassified according to the effects of lithium exposure during the pretreatment phase and these are shown in the circles in the periphery. For the original "no change" group, in the presence of lithium if the ratio was (a) <0.5 they were classified as "tolerance", (b) > 1.5 they were classified as "sensitization", and (c) 0.5 – 1.5 they were classified as "no change". For the original "tolerance" group, in the presence of lithium if the ratio was (a) still <0.5 and at least 0.1 lower than without lithium they were classified as "more tolerance", (b) still <0.5 and equal or greater than the ratio without lithium they were classified as "no change", and (c) >0.5 they were classified as "blocked tolerance". For the original "sensitization" group, in the presence of lithium if the ratio was (a) <0.5 they were classified as "tolerance", (b) 0.5 – 1.5 they were classified as "blocked sensitization", (c) still >1.5 they were classified as "no change".