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. Author manuscript; available in PMC: 2011 Aug 15.
Published in final edited form as: Dev Biol. 2010 Jun 1;344(2):707–719. doi: 10.1016/j.ydbio.2010.05.503

Figure. 6. Curcumin treatment suppresses STAT3 activation and epidermal hyperplasia.

Figure. 6

E16.5 embryos were dissected from pregnant females injected i.p. with curcumin or vehicle daily for 2 days. Dorsal skin sections from Fatp4−/− and control littermates were then subjected to hematoxylin and eosin staining (A-D) or immunohistochemical analyses (E-T). Some sections were counterstained with hematoxylin (E-L). (A-D) Curcumin treatment suppressed the thickened epidermis phenotype (compare white brackets in B and D) but not the flat skin phenotype (compare C to D). (E-H) Nuclear localization of pSTAT3 was dramatically reduced by curcumin (compare F to H; arrowheads in H mark residual nuclear signals). (I-L) Curcumin treatment drastically reduced the ectopic activation of keratin 6 (compare J to L). (M-P) Ectopic EGFR activation in mutant suprabasal cells was moderately suppressed by curcumin (compare N to P). (Q-T) Curcumin treatment also moderately reduced ectopic JAK2 activation in mutant suprabasal layers (arrowheads in R; compare R to T). Dashed lines demarcate the dermo-epidermal boundary. Hair follicle progenitors are indicated by asterisks. Scale bar is 50 μm.