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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Neuroscience. 2010 Jun 10;169(3):1127–1135. doi: 10.1016/j.neuroscience.2010.06.006

Figure 5.

Figure 5

Cocaine primed reinstatement of drug-seeking behavior. (A-C) Data are the mean ± SEM of active lever presses for the indicated treatment groups (n= 8,9,8,8, respectively) during 30 min periods before (left bar) and after (right bar) noncontingent i.v. drug priming at the indicated doses. (A) Following a single 0.25mg/kg infusion, active lever responding did not differ significantly among all groups. (B) Following a single 0.5mg/kg infusion, active lever responding was significantly increased in both the saline extinguished and saline abstinent groups (**, p<0.01; *, p<0.05; two-way ANOVA/Holm-Sidak), and responding of the D-serine treatment groups was significantly decreased as compared with the saline abstinent group (††, p<0.01; †, p<0.05; two-way ANOVA/Holm-Sidak). Also, the D-serine pretreatment group was significantly decreased as compared with the saline extinction group (#, p<0.05; two-way ANOVA/Holm-Sidak). (C) Following a single 1mg/kg infusion, active lever responding was significantly increased in both the saline extinguished and saline abstinent groups (**, p<0.01; two-way ANOVA/Holm-Sidak), and responding of the D-serine treatment groups was significantly decreased as compared with either the saline abstinent group (††, p<0.01; two-way ANOVA/Holm-Sidak) or the saline extinction group (#, p<0.05; two-way ANOVA/Holm-Sidak). (D) Summary dose-response of the active lever presses for the indicated treatment groups and drug priming doses. Note that 0.5mg/kg was used during cocaine self-administration.