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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Mol Pharm. 2010 Aug 2;7(4):1209–1222. doi: 10.1021/mp100043h

Scheme 1.

Scheme 1

Schematic representation of the synthesis of three dimensional hydrophilic HBPH polymer (4) and its functional HBPH nanoparticles (HBPH NPs). The monomer 3 with three-bond connectivity polymerized three-dimensionally, resulting in a highly branched polymer with amphiphilic cavities in the polymeric structure.