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. Author manuscript; available in PMC: 2011 Oct 28.
Published in final edited form as: Cancer Lett. 2010 Oct 28;296(2):168–177. doi: 10.1016/j.canlet.2010.04.005

Fig. 2.

Fig. 2

Chemotherapy drugs more efficiently inhibit neurosphere formation than bulk cell proliferation. We calculated the concentrations of chemotherapy drug required to inhibit neurosphere formation by 50% (sphere IC50), the concentrations of drug required to inhibit bulk cell proliferation by 50% (MTS/MTT IC50) and the concentrations required to inhibit bulk cell proliferation by 90% (MTS IC90)(A–D). Also, normal neurosphere bulk cells are more sensitive to chemotherapy drugs than the transformed PET2 cells (A–B).