The effects of prenatal and postnatal MPTP on motor activities in C57BL/6J mice. The measures were made 24 hours after the last postnatal injection of MPTP (10, 20 or 30 mg/kg) or PBS in the 12 weeks prenatal PBS-exposed and prenatal MPTP-exposed offspring. The total distance traveled (TD, A), the number of movements (NM, B) and the movement time (MT, C) are shown and were determined using an activity monitor (Degiscan Instruments Inc., Columbus, OH, USA). Values are expressed as means ± SEM of 15 animals. Data were analyzed by using student-t test with P≤ 0.05. Dose-response effects are seen for both prenatal PBS and MPTP mice. Asterisks (*) indicate significant differences for the MPTP group from the respective PBS controls.